Summaries by Inventor Sedy, John

Hamster Hybridoma producing Monoclonal Antibody against Murine CD272 (BTLA)
Hurchla, Michelle ; Murphy, Kenneth ; Murphy, Theresa ; Sedy, John
T-004458

— Target: B and T lymphocyte attenuator (BTLA). BTLA is expressed on peripheral lymphocytes, splenic macrophages and select developing B and T cells.Inventors created the monoclonal antibodies by immunizing Armenian hamster or BALB/c background BTLA -/- mice. Hamster monoclonal 6A6 is of the IgG isotype, whereas all murine Abs are IgG1κ. Some of the antibodies recognize the mouse BTLA C57/BL6 allele (6A6, 3F9.C6) and some are panspecific (…